CRE Loaded 6 or simply Loaded is it is more frequently called, is a version of osCommerce 2.2 MS2 which has been preloaded with a number of very useful extras to help emerchants get their stores up and working faster, and keep them working more efficiently without the added hassle of having to add additional modules to the store right away.  CRE Loaded has been an excellent addition to the osCommerce and Open Source communities.